CCL21 and cancer: In Moffitt Cancer Center, a phase I clinical trial was initiated to assess the toxicity, immune responses, and anti-tumor clinical responses in human leukocyte antigen-A*0201-positive patients with chemotherapy-naive metastatic melanoma receiving escalating doses of adenoviral CCL21-transduced DC matured ex vivo with a cytokine cocktail and pulsed with MART-1/gp100/NY-ESO-1 class I peptides and keyhole limpet hemocyanin [52].