CD4 and neoplasm: CCL21 mediated immune response included an increased influx of CD4 and CD8 T cells and DC in the tumor, as well as increased IFN-γ, MIG-CXCL9, CXCL10, GM-CSCF and IL-12, but a concomitant decrease in immunosuppressive molecules such as PGE-2 and TGF-β [8].