CDKN2B-AS1 and Familial prostate cancer: Kyoko et al has showed that higher levels of lncRNA ANRIL expression were seen in prostate cancer and involved in repressing of the p15/CDKN2B-p16/CDKN2Ap14/ ARF gene cluster in Cis by directly binding to the Polycomb Repressor Complex (PRC) [22].