Strikingly, the high IGF-1R (well:40.5% (15/37); Moderate:61.5% (8/13); poor:85.7% (12/14)) and IRS-2(well:56.8%(21/37); Moderate:69.2%(9/13); poor:92.9%(13/14)) levels were significantly associated with poor tumor histology(P=0.013, P=0.036, respectively), but not with age, gender and TNM stage, suggesting that upregulated IGF-1R and IRS-2 proetin expression might be involved in the progression of OSCC. This evidence concerns the gene IGF1R and neoplasm.