In addition to PKCθ, lack of PKCɛ resulted in interstitial fibrosis when the mice were subjected to pressure overload by transverse aortic constriction.24 In addition, PKCɛ has a protective role against cardiomyocyte apoptosis during cardiac ischemia/reperfusion injury.20 However, simultaneous loss of PLCδ1 and PLCδ3 did not affect the activation status of PKCɛ. The gene discussed is PLCD3; the disease is myocardial ischemia.