This diversity between highly homologous receptors that potentially interact with common ligands may result from higher order receptor complexes, interactions with membrane proteins or unique intracellular signaling intermediates.39 Functional diversity may also exist for an individual receptor; for example, EphB3 has been demonstrated to have opposing effects on non-small-cell lung cancer metastasis. The gene discussed is EPHB3; the disease is non-small cell lung carcinoma.