CALCA and infection: However, at day 3 post-infection, the Socs4R108X/R108X mice showed significantly higher levels of cytokines and chemokines, such as IL-1β, IL-4, IL-5, IL-6, IL-12p40, IL-13, IFN-γ, and KC (CXCL1), MIP-2 (CXCL2) and MCP-1 (CCL2), respectively (Fig. 2A).