CD8A and infection: In addition to the early excessive inflammation, we observed a clear difference in the distribution of virus-specific CD8 T cells in Socs4R108X/R108X mice, with tetramer positive cells appearing to accumulate in the spleen of Socs4R108X/R108X mice instead of migrating to the site of infection, and this discrepancy was particularly apparent by day 5 post-infection (Fig. 3B).