HSP90B2P and infection: The effect on viral replication by the duplicate siRNA sets (i.e., two independent siRNA constructs targeting the same HSP gene) correlates well with their respective silencing efficiencies (Figures 7 and 8A); thus, in the duplicate sets, those siRNA constructs that give greater knockdowns of their target HSP also give a larger reduction in the level of infection, further indicating the specificity of the effects of the siRNAs on viral load.