Analyses examining each risk factor and CIS score (table 3) indicate that those belonging to CIS 0 (always been in the highest social class) had the lowest mean Framingham score, fibrinogen, CRP and vWF levels, low prevalence of current smoking, low rates of physical inactivity, higher consumption of alcohol and low prevalence of obesity compared to those with higher CIS scores (P<0.01). This evidence concerns the gene VWF and in situ carcinoma.