Okada et al. (33) conducted a phase I/II trial to evaluate the safety and immunogenicity of a vaccine using polarized dendritic cells loaded with polyinosinic–polycytidylic acid stabilized by lysine and carboxymethylcellulose (poly-ICLC) and synthetic peptides for glioma-associated antigens including YKL-40. This evidence concerns the gene CHI3L1 and central nervous system cancer.