In another report by Liu et al. that utilized the culture of glioblastoma dissociated cells under stem cell conditions with subsequent differentiation in the presence of serum, EDN3 mRNA, known to be involved in the development of neural crest-derived cells lineages, and CD133 mRNA were decreased under differentiation conditions while EDN1 and YKL-40 mRNA were upregulated (10). The gene discussed is CHI3L1; the disease is glioblastoma.