TAMs comigrate with carcinoma cells due to the presence of a CSF-1 EGF paracrine loop; carcinoma cells secrete CSF-1 and express the EGF receptor and macrophages secrete EGF and express the CSF-1 receptor stimulating each other to migrate via EGF activation of the N-WASP signalling pathway and formation of invadopodia [43]. The gene discussed is CSF1; the disease is carcinoma.