PTGS2 and cancer: Another study by Okada et al. [36] demonstrated that 2-methoxy-4-propylphenol induces apoptosis and is a potent inhibitor of lipopolysaccharide (LPS)-induced cyclooxygenase-2 (COX-2) gene expression, in which, the overexpression of the COX-2 gene protects cancer cells from apoptosis.