The significant increase in hormone metabolism in CROHNS may point to the difference in bone mineral density (Ardizzone et al., 2000) while the increased response in growth hormone in CROHNS may be directly related to growth hormone therapies specific to the treatment of Crohn's Disease (Slonim et al., 2000; Heyman et al., 2008). The gene discussed is GH1; the disease is Crohn disease.