VDR and colonic neoplasm: Furthermore, the authors showed positive correlation between KDM6B and VDR in 96 colon tumor patients, and inverse correlation of KDM6B with SNAIL1, which is involved in epithelial to mesenchymal transition, indicating that probably the antiproliferative role of 1,25-D3 via KDM6B upregulation might take place in vivo (Pereira et al., 2011).