In addition, genetic variations of the TTBK1 gene (SNPs rs2651206, rs10807287, and rs7764257) are associated with late-onset Alzheimer’s disease (LOAD) in two large cohorts of Spanish and Chinese populations (Vazquez-Higuera et al., 2011; Yu et al., 2011), further validating the importance of the TTBK1 gene in the development of tauopathy and AD pathogenesis (Cuny, 2009). Here, TTBK1 is linked to early-onset autosomal dominant Alzheimer disease.