Further studies are necessary to characterize the association of TTBK1 polymorphism, TTBK1 expression, pre-tangle formation and neuroinflammation in AD cases, and to see if reduction in TTBK1 level by TTBK1 gene targeting or silencing delays the progression of tau pathology in established tau mouse models for pre-clinical validations. The gene discussed is MAPT; the disease is Alzheimer disease.