NPCs are therefore able to prevent inflammation-induced neuronal programmed cell death and glial scar formation—occurring, for example, in EAE, SCI, stroke—mainly via the paracrine secretion of the nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), and glial-derived neurotrophic factor (GDNF) (Teng et al., 2002; Lu et al., 2003; Pluchino et al., 2003, 2005; Chu et al., 2004; Ryu et al., 2004; Ziv et al., 2006; Redmond et al., 2007; Bacigaluppi et al., 2009). This evidence concerns the gene GDNF and stroke disorder.