IL4 and neoplasm: In the tumor-bearing mice that were treated with the pNGVL3-mIL-12 plasmid, the intratumoral cytokine expression profile was affected, showing a significant decrease in expression of IL-4, IL-10, and TGF-β1 (Th2/Th3-type cytokines) (P value < 0.001) after the first administration of plasmid, which correlated with inhibition of tumor growth.