NOS3 and Myocardial fibrosis: The key findings were as follows: i) muscone improved the survival rate and exercise tolerance, as well as the cardiac structure and function; ii) muscone attenuated myocardial fibrosis and inflammation following MIl iii) muscone exerted anti-apoptotic effects by increasing Bcl-2 and decreasing Bax expression; iv) muscone increased the phosphorylation of Akt-eNOS.