Following exposure of CD34+ CML cells to TKIs for 24 hours, levels of ATM, BCL6, and CDKN1C/p57 were modulated in the anticipated direction in response to active FOXO TFs and induction of quiescence, pooled results are shown (Fig. 3B). Here, CDKN1C is linked to chronic myelogenous leukemia, BCR-ABL1 positive.