CD34+ CML cells were treated with 150 nM dasatinib for 24 hours, at which time IF showed relocalization of total FOXO1 and 3a from cytoplasm (Fig. 2D, a–f) to nucleus (Fig. 2D, k–p), while little effect was seen with FOXO4. The gene discussed is FOXO4; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.