FOXO3 and chronic myelogenous leukemia, BCR-ABL1 positive: Indeed FOXO3a TM alone inhibited proliferation to a similar degree as 24 hours incubation with 10 nM dasatinib (used at lower concentration as these cells are more sensitive than primary CD34+ CML cells), confirming FOXO3a plays an important role in the cell cycle regulation of these cells.