Furthermore, PAK4 and PAK6 have much lower MLs than PAK7 in six cancers; PAK4, PAK6 and PAK7 are 14-3-3-binding phosphoproteins [42,46]; PAK4 was 14-3-3-affinity captured here from melanoma cell lysates; and overexpressed PAK4 and PAK6 were more effective than PAK7 in enhancing the viability of B-RafV600E-mutant melanoma cells exposed to PLX4720 [43]. This evidence concerns the gene PAK5 and melanoma.