miR-380 which is highly expressed in NB repress p53-mediated apoptosis, and is associated with poor outcome in NB with MYCN amplification. miR-380 overexpression cooperates with activated HRAS oncoprotein and form tumors in mice. Inhibition of miR-380-5p in embryonic stem or NB cells results in induction of p53, and apoptotic cell death.In vivo delivery of a miR-380-5p antagonist decreases tumor size in NB orthotopic mouse model suggesting a promising potential therapeutic ability to miR-380 inhibitors. The gene discussed is TP53; the disease is neoplasm.