miR199b-5p target Notch effector HES1, which is involved in MB pathogenesis. miR199b-5p overexpression impairs the clonogenic potential of MB cell lines. Moreover MB tumor infection by adenovirus carrying miR199b-5p in a xenograft model reduces the tumor burden in vivo suggesting possible use of miR199b-5p as an adjuvant therapy. Here, HES1 is linked to neoplasm.