RHO and cancer: Recent studies reveal the anti-cancer effects induced by GLA, that it prevents the oxidative DNA fragmentation in UVB-irradiated human keratinocyte HaCaT cells [28]; meanwhile, it blocks the proliferation of human breast cancer cells [8]; moreover, it inhibits the migration, invasion, and angiogenesis by inhibiting the FAK/Rho signaling pathway [29]; further, it also enhances the efficacy of chemotherapy by inhibiting P-glycoprotein and multidrug resistance protein 1 synthesis [30].