We compared the RNase A level of patients with 11 kind of cancers with that of healthy controls, and found the serum RNase A level in patients with cervical cancer, esophageal cancer, kidney cancer, lung cancer, bladder cancer, pancreatic cancer, ovary cancer, liver cancer and gastric cancer are significantly down-regulated when compared with that of healthy controls (P<0.001), while the serum RNase level of breast cancer and colon cancer patients was not very significantly different from that of healthy individuals. This evidence concerns the gene RNASE1 and liver cancer.