CRIPTO and infectious otitis media: Colons from untreated wt (Fig. 1A and A′) and Cripto+/− (data not shown) mice did not show apoptotic nuclei in colon crypts, whereas numerous apoptotic nuclei were detected in colons of both wt (Fig. 1B and ′) and Cripto+/− (Fig. 1C and C′) mice treated with AOM.