CD40LG and hyperinsulinemic hypoglycemia, familial, 4: Based on the strong correlation in the blood levels of AIM and IgM [22], patients with genetic immunoglobulin deficiencies (X- or autosome-linked infantile agammaglobulinemia) or severe combined immunodeficiency (SCID), who exhibit null or very low natural IgM levels, may also show low AIM levels.