MAPK3 and hyperhomocysteinemia: On the other hand, hyperglycemia impairs c-Kit+ CSC migration via a reduction in the activity of ERK1/2 and p38 (32), and hyperhomocysteinemia inhibits the homing of CSCs to peri-infarcted areas post-MI in rats with an associated mechanism that may be due to the inhibition of NF-κB (33).