UCP3 and obesity due to melanocortin 4 receptor deficiency: It is worth noting that a previous meta-analysis from our group showed an association of the UCP3-55C/T polymorphism with risk for type 2 diabetes mellitus in Asians (OR = 1.22, 95% CI 1.04–1.44, allele contrast model) [81], further indicating a role for this polymorphism in obesity-related features.