PPP1R1B and Lesch-Nyhan syndrome: In order to demonstrate that the changes in Bcl11b and Ppp1r1b/DARPP-32 gene expression are not unique to murine cells or tissues, we comparatively examined the expression profile of Bcl11b and Ppp1r1b/DARPP-32 mRNA in primary culture of fibroblast cells derived from control (normal) and LNS patients.