Thus, in the present study we investigated whether a) the growth-inhibitory effects of CR in the Panc02 tumor model could be linked via reduced IGF-1 levels to a reduction in NF-κB activity and subsequent reduction of pro-inflammatory mediators and b) the elevated levels of circulating IGF-1 observed in response to positive energy balance could enhance activity of NF-κB. Here, NFKB1 is linked to neoplasm.