NFKB1 and cancer: Activation of NF-κB by mTOR pathway activation leads to the phosphorylation of the NF-κB inhibitory protein, IκBα, which is targeted for ubiquitination by the 26S proteasome allowing the active NF-κB subunit, p65, to translocate to the nucleus and intiate transcription of multiple genes associated with inflammation and cancer development [18], [19].