Because gp130757FF mice develop tumours in response to constitutive gp130 activation [20], we tested whether WP1066 suppressed downstream signalling pathways in vivo. WP1066 treatment for 2 weeks resulted in a 25% decrease in the relative amount of total STAT3 in the antral mucosa compared to DMSO treated groups (Fig. 4A). Here, STAT3 is linked to neoplasm.