Apart from the well established autocrine regulation of amphiregulin [40] via STAT3, this growth factor can also be induced in a COX2/PGE2-dependent fashion in mouse models of gastric tumour development [41], and since COX2 was also inhibited by WP1066 then it may also contribute to the inhibition of amphiregulin. This evidence concerns the gene STAT3 and gastric neoplasm.