Detection of novel variants in GRM7 associated with BP was pursued by resequencing all the exons in all the GRM7 isoforms, exon/intron boundaries, ∼3 kb of the promoter region of the isoforms ENST00000486284 and ENST00000463676, and 1 kb of the promoter region of the isoform ENST00000458641, 5′-UTR and 3′-UTR of the GRM7 gene in 32 bipolar cases and 32 random controls. This evidence concerns the gene GRM7 and bipolar disorder.