The combination of cisplatin and radiation, commonly used to treat cervical cancer, induces calreticulin exposure, HMBG1 and ATP release, and three signals that accompany the process of “immunogenic cell death.” Interestingly, calreticulin exposure has been described as an ancestral stress response that is able to be subverted by viruses, including HPVs [64, 65]. This evidence concerns the gene CALR and cervical carcinoma.