Animal models of tumorigenesis use tubal epithelial cells and result in high-grade mullerian cancers similar to high-grade human ovarian serous cancers from a molecular point of view [80, 81]; another interesting study has recently described a high-grade serous ovarian cancer model with knockout of Brca1 or 2, TP 53, and Pten. Here, PTEN is linked to ovarian serous adenocarcinoma.