In our research, we selected four potentially functional polymorphisms (The PDCD-1 −606A/G (rs rs36084323) in promoter, PDCD-1 +7146A/G (rs11568821) in intron 4, and PDCD-1 +7625G/A (rs2227982) and PDCD-1 +7786G/C (rs2227981) in exon 5) of PDCD-1 gene and identified the association between the four polymorphisms and the risk of RA in Southeastern Chinese population. The gene discussed is PDCD1; the disease is rheumatoid arthritis.