Previously, 2LOmb identifies 11 intronic SNPs which exhibit no marginal single-locus effects and are associated with type 2 diabetes mellitus (T2D) in a UK population (The Wellcome Trust Case Control Consortium 2007): four SNPs in PGM1 (phosphoglucomutase 1), two SNPs in LMX1A (LIM homeobox transcription factor 1, alpha), two SNPs in PARK2 (parkinson protein 2, E3 ubiquitin protein ligase (parkin)) and three SNPs in GYS2 (glycogen synthase 2 (liver)). The gene discussed is UBE2E3; the disease is type 2 diabetes mellitus.