Blocking RAAS with valsartan in combination with fluvastatin (a statin) in atherosclerosis mouse model, the apolipoprotein E (ApoE−/−) null mice, reduces the level of atherosclerotic lesions, superoxide anion, and the expression level of MCP-1 and ICAM-1, indicating that blocking inflammation and oxidative stress has beneficial effects on endothelium [58]. The gene discussed is CCL2; the disease is atherosclerosis.