Blocking RAAS signaling either with ACEIs which inhibit the formation of angiotensin, or ARBs which block angiotensin receptors, or DRIs which inhibit the renin-angiotensinogen reaction, or MRAs which block aldosterone, alone or in combinations, reduces mortality and morbidity in diabetes, hypertension, atherosclerosis, heart failure, and stroke [69]. This evidence concerns the gene REN and Hypertension.