Particularly promising results have been obtained by targeting prostate-specific membrane antigen (PSMA), a type II transmembrane glycoprotein also known as glutamate carboxypeptidase II, and folate hydrolase I, which is basally expressed by prostate epithelial cells and overexpressed in primary and metastatic prostate cancer [3, 4, 15]. The gene discussed is FOLH1; the disease is metastatic prostate carcinoma.