In fact, the incidence of 18% and 43% of M3v and of the bcr3 isoform in the PETHEMA pediatric series do not differ from the 19% and 44% reported for the whole series of APL patients included in the PETHEMA LPA96 and LPA99 studies.2,3,5–7. The gene discussed is BCRP3; the disease is acute promyelocytic leukemia.