A low incidence of additional cytogenetic rearrangements has been reported in pediatric APL by Raimondi at al. and in children included in the European APL93 trial (11% of children vs 27% of adults carrying chromosomal abnormalities in addition to PML/RARα).35 On the contrary, these findings were not confirmed by Ortega at al. in the PETHEMA LPA96 and LPA99 trials in which the proportion of children with additional chromosomal abnormalities did not differ from that reported in the PETHEMA study of adult patients.2,3,7. Here, RARA is linked to acute promyelocytic leukemia.