F2R and neoplasm: It was found that PAR-1 can promote tumor growth, invasion and metastasis.24 In addition PAR-1 activation stimulates proliferation and decreases idarubicin induced cell death in vitro.28 The zinc-dependent matrix metalloprotease 1 (MMP-1), also known as interstitial collagenase, has been reported to promote tumor growth and invasion through activation of PAR-1, providing an important link between tumor-generated metalloproteases and PAR-1 expression (Boire et al., 2005).24