F2R and Splenomegaly: There were no significant differences between PAR-1 positive and PAR-1 negative patients regarding age, sex, pallor, purpura, hepatomegaly and splenomegaly while there was statistically significant difference between PAR-1 positive and PAR-1 negative patients regarding lymphadenopathy with a higher incidence of lymphadenopathy in PAR-1 positive patients.