LRRK2 and Parkinson disease: Of interest, sequencing has revealed mutations of the LRRK2 gene at a frequency of 8% [5]. LRRK2 encodes a serine-threonine kinase responsible for phosphorylating the eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1), a protein which functions in regulating protein translation. LRRK2 is predominantly known for its association with Parkinson's disease, where mutations in the gene are linked to a predisposition for the condition [113, 114].