In order to clarify the weight of +896 TLR4 A/G polymorphism as potential predisposing or protective genetic factor in the major T2DM complications (neuropathy, nephropathy, chronic kidney failure, chronic arterial disease of the lower limbs, carotid arterial diseases, and ischemic heart diseases) in the Caucasian population, we analysed 367 patients affected by T2DM and with complications for the 55.6%. Here, TLR4 is linked to Nephropathy.