Thus, the key aim of the present study was to analyze the weight of +896 TLR4 A>G SNP as potential predisposing or protective genetic risk factor in the major T2DM complications evaluating a population of 367 patients affected by T2DM and with complications for the 55.6%, including neuropathy, nephropathy, chronic kidney failure, chronic arterial disease of the lower limbs, and MACE. The gene discussed is TLR4; the disease is type 2 diabetes mellitus.