The pathways which have the most RASopathy proteins participating are downstream of the B‐ and T‐cell receptors, the epidermal growth factor receptor (EGFR), Kit receptor, oncostatin (OSM) receptor, prolactin, fibroblast growth factor receptor (FGF‐1), brain‐derived growth factor receptor (BDNFR), different interleukin receptor family members, tumour necrosis factor alpha (TNF‐α) receptor and transforming growth factor beta (TGF‐β) (Supplementary Fig S3). This evidence concerns the gene PPIB and RASopathy.