For example, the down-regulation of miR-30 family and miR-107 can up-regulated p53 expression in human cell lines (Li et al., 2010), and overexpression of miR-125b represses the endogenous level of p53 protein and suppresses apoptosis in human neuroblastoma cells and human lung fibroblast cells (Le et al., 2009). This evidence concerns the gene TP53 and neuroblastoma.