The interaction between murine B16 melanoma and the HSE involves mannose receptor–mediated melanoma cell attachment to the HSE, which causes subsequent proinflammatory cytokine release (i.e., TNF-α, IL-1β, and IL-18), as well as VCAM-1–dependent adherence that reinforces or locks the initial intercellular binding [2] (see Fig. 6B). Here, TNF is linked to melanoma.