For this analysis, of the nine selected DPSs, we selected the two up-regulated phosphosites [STAT3(Y705) and Rela(S534)] and also the two down-regulated phosphosites [PKCδ/θ(S643/676) and Akt1(S473)] to include the two known and two unknown phosphorylations in association with AD pathogenesis (see above). This evidence concerns the gene AKT1 and Alzheimer disease.