MAPK8 and Alzheimer disease: Among the total of nine DPSs (3 and 7 DPSs in two and six months, respectively), the alterations of the six phosphorylation sites [STAT5a/b(Y694/Y699) [23], STAT3(Y705) [24], Akt1(S473) [25], JNK1(T183/Y185) [26], [27], GSK3b(S9) [28] and EGFR(Y1069) [29]] were previously shown to be associated with AD pathogenesis, which supports the validity of the DPA.