Constitutive knockout of methionine adenosyltransferase 1 alpha (Mat1a), which encodes the enzyme responsible for converting hepatic methionine to SAM, results in its depletion and promotes spontaneous NASH that progresses to HCC (Lu et al. 2001; Martinez-Chantar et al. 2002). This evidence concerns the gene MAT1A and hepatocellular carcinoma.