PIK3CA and metabolic dysfunction-associated steatotic liver disease: Upregulation of PPAR-γ has also been mechanistically linked to steatohepatitis in models generated through genetic disruption of the PI3K/AKT (Horie et al. 2004; Kudo et al. 2011) and JAK/STAT (Mueller et al. 2011; Sos et al. 2011) signaling pathways, indicating the broad importance of this molecule in the pathogenesis of progressive NAFLD.