BDNF and neuronal tumor: Although both TrkB and p75NTR involved in proliferation, differentiation, survival and apoptosis of neuronal and non-neuronal tumors [7], [8], p75NTR preferentially acts as an interacting partner of TrkB, modulates TrkB activation by BDNF, and influences prosurvival effect by BDNF/TrkB signaling [9].