As shown in Fig. 4A and 4B, both Iressa (an EGFR targeted anti-tumor drug) treatment and PI4KIIα knockdown inhibited MCF-7 tumor growth, which is consistent with our previous results showing that downregulation of PI4KIIα results in nearly complete inhibition of MCF-7 cell-induced tumor growth in vivo (Li et al., 2010). The gene discussed is EGFR; the disease is neoplasm.