Taking these points into account, PI4KIIα is undoubtedly an ideal target for tumor therapy: (i) PI4KIIα knockdown increases EGFR degradation in a subtype-specific manner, since PI4KIIα is just one subtype within the PI4K family, specific downregulation of PI4KIIα is unlikely to induce complicated side effects, as other PI4K family members remain functional. This evidence concerns the gene EGFR and neoplasm.