Other studies showed that PI4KIIα is involved in pathways related to tumor progression, for example, Pan et al. (Pan et al., 2008) and Qin et al. (Qin et al., 2009) reported that PI4KIIα is important for WNT signaling pathway; Chu et al., (2010) reported that PI4KIIα subtype specifically influences AKT activity. This evidence concerns the gene AKT1 and neoplasm.