In L.g. LRVlow infected mice, there was no consistent modulation of IL-12p35 as compared to WT mice at both time points analyzed (Fig. 3A), whilst IL-12p40 transcripts were diminished in MyD88−/− and TLR9−/−mice only at 4 weeks post infection (Fig. 3A). The gene discussed is MYD88; the disease is infection.