Insect heat shock proteins (Hsp) are important molecular chaperone which were the first introduced by Tissieres et al. (1974) [42] due to its increased expression to the high temperature in D. melanogaster, and it also has been confirmed that Hsp involved in multiple physiological roles such as to increase lifespan, enhance stress resistance, and prevent apoptosis and neurodegenerative diseases [43], [44]. The gene discussed is HSP90B2P; the disease is neurodegenerative disease.