Interestingly, here we showed that downregulation of IQGAP1 led to a reversion of EMT progress, characterized by decreased expression of mesenchymal markers N-catenin and increased expression of epithelial markers E-cadherin, which was in agreement with IQGAP1 knockdown inhibiting invasion and metastasis of ESCC cell lines in vitro and in vivo. This evidence concerns the gene IQGAP1 and esophageal squamous cell carcinoma.