Interestingly, here we showed that downregulation of IQGAP1 led to a reversion of EMT progress, characterized by decreased expression of mesenchymal markers N-catenin and increased expression of epithelial markers E-cadherin, which was in agreement with IQGAP1 knockdown inhibiting invasion and metastasis of ESCC cell lines in vitro and in vivo. The gene discussed is CDH1; the disease is esophageal squamous cell carcinoma.